Drug interactions
Budesonide-formoterol + Isoproterenol
Severity: Major
Budesonide-formoterol and Isoproterenol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are beta-adrenergic agonists, so combined use produces additive tachycardia, tremor, hypertension or hypotension, arrhythmias and hypokalemia. This duplication of therapy increases the risk of cardiovascular toxicity.
What this interaction means in plain words
Budesonide-formoterol and Isoproterenol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Budesonide-formoterol belongs to Respiratory; Isoproterenol belongs to Respiratory.
Why it happens
Additive beta-adrenergic receptor agonism.
What to do
Avoid concurrent use where possible; if isoproterenol is required, monitor heart rate, ECG, blood pressure and potassium closely. Hold formoterol during isoproterenol infusion where feasible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Budesonide-formoterol
Other interactions of Isoproterenol
Frequently asked questions
Can I take Budesonide-formoterol with Isoproterenol?
MediHelp rates the interaction as major. Budesonide-formoterol and Isoproterenol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are beta-adrenergic agonists, so combined use produces additive tachycardia, tremor, hypertension or hypotension, arrhythmias and hypokalemia. This duplication of therapy increases the risk of cardiovascular toxicity.
How serious is the interaction between Budesonide-formoterol and Isoproterenol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; if isoproterenol is required, monitor heart rate, ECG, blood pressure and potassium closely. Hold formoterol during isoproterenol infusion where feasible.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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