Drug interactions
Dextroamphetamine + Lorazepam
Severity: Minor
Dextroamphetamine and Lorazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextroamphetamine is a stimulant and lorazepam a sedative, so their effects on alertness oppose each other. Stimulation may mask sedation from lorazepam without reducing its effects on psychomotor performance, and the clinical effect is unpredictable.
What this interaction means in plain words
Dextroamphetamine and Lorazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dextroamphetamine belongs to Central Nervous System; Lorazepam belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on the CNS (stimulant versus GABA-A mediated sedation); no pharmacokinetic interaction is established.
What to do
No routine adjustment is needed. Warn patients not to rely on perceived alertness when judging fitness to drive, and monitor for anxiety or insomnia and for excess sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dextroamphetamine and Lorazepam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lorazepam
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Lorazepam?
MediHelp rates the interaction as minor. Dextroamphetamine and Lorazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dextroamphetamine is a stimulant and lorazepam a sedative, so their effects on alertness oppose each other. Stimulation may mask sedation from lorazepam without reducing its effects on psychomotor performance, and the clinical effect is unpredictable.
How serious is the interaction between Dextroamphetamine and Lorazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Warn patients not to rely on perceived alertness when judging fitness to drive, and monitor for anxiety or insomnia and for excess sedation.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
