Drug interactions
Dextroamphetamine + Methadone
Severity: Minor
Dextroamphetamine and Methadone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextroamphetamine is a stimulant that may offset methadone-related sedation, but it does not reduce respiratory depression risk. Both agents can affect cardiovascular function, and the net effect is unpredictable.
What this interaction means in plain words
Dextroamphetamine and Methadone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dextroamphetamine belongs to Central Nervous System; Methadone belongs to Musculoskeletal.
Why it happens
Opposing pharmacodynamic effects on CNS arousal; no established pharmacokinetic interaction.
What to do
No routine change is required; monitor heart rate, blood pressure and mental status. Do not rely on the stimulant to mask sedation from methadone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Methadone?
MediHelp rates the interaction as minor. Dextroamphetamine and Methadone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dextroamphetamine is a stimulant that may offset methadone-related sedation, but it does not reduce respiratory depression risk. Both agents can affect cardiovascular function, and the net effect is unpredictable.
How serious is the interaction between Dextroamphetamine and Methadone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is required; monitor heart rate, blood pressure and mental status. Do not rely on the stimulant to mask sedation from methadone.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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