Drug interactions
Dextroamphetamine + Morphine
Severity: Moderate
Dextroamphetamine and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines can offset opioid sedation and may enhance opioid analgesia, but the combined effects are unpredictable. Amphetamines also have serotonergic activity, so serotonin toxicity is a theoretical concern.
What this interaction means in plain words
Dextroamphetamine and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Morphine belongs to Musculoskeletal.
Why it happens
Opposing CNS stimulant and depressant effects, with a possible additive serotonergic contribution.
What to do
Monitor for signs of serotonin syndrome and for masked opioid sedation. Do not use stimulant effects to justify higher opioid doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Morphine?
MediHelp rates the interaction as moderate. Dextroamphetamine and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines can offset opioid sedation and may enhance opioid analgesia, but the combined effects are unpredictable. Amphetamines also have serotonergic activity, so serotonin toxicity is a theoretical concern.
How serious is the interaction between Dextroamphetamine and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin syndrome and for masked opioid sedation. Do not use stimulant effects to justify higher opioid doses.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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