Drug interactions
Dextroamphetamine + Pseudoephedrine
Severity: Moderate
Dextroamphetamine and Pseudoephedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents release catecholamines, so together they produce additive increases in blood pressure and heart rate and can cause palpitations, anxiety, insomnia or arrhythmia. Patients with hypertension or heart disease are at greater risk.
What this interaction means in plain words
Dextroamphetamine and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Pseudoephedrine belongs to Respiratory.
Why it happens
Additive indirect sympathomimetic activity via norepinephrine release.
What to do
Avoid routine use of decongestants with amphetamines; monitor blood pressure and heart rate if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pseudoephedrine
- Isocarboxazid + Pseudoephedrine Contraindicated
- Phenelzine + Pseudoephedrine Contraindicated
- Pseudoephedrine + Rasagiline Contraindicated
- Pseudoephedrine + Selegiline Contraindicated
- Pseudoephedrine + Selegiline transdermal Contraindicated
- Pseudoephedrine + Tranylcypromine Contraindicated
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Pseudoephedrine?
MediHelp rates the interaction as moderate. Dextroamphetamine and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents release catecholamines, so together they produce additive increases in blood pressure and heart rate and can cause palpitations, anxiety, insomnia or arrhythmia. Patients with hypertension or heart disease are at greater risk.
How serious is the interaction between Dextroamphetamine and Pseudoephedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine use of decongestants with amphetamines; monitor blood pressure and heart rate if needed.
What other medicines interact with Pseudoephedrine?
MediHelp also lists interactions of Pseudoephedrine with, for example, Isocarboxazid, Phenelzine, Rasagiline. The full list is on the Pseudoephedrine page.
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