Drug interactions
Dextroamphetamine + Salmeterol
Severity: Moderate
Dextroamphetamine and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have sympathomimetic activity, so combined use can increase heart rate, blood pressure, tremor and anxiety. Patients with cardiovascular disease or arrhythmias are at greater risk.
What this interaction means in plain words
Dextroamphetamine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Salmeterol belongs to Respiratory.
Why it happens
Additive adrenergic stimulation, via direct beta-2 agonism and amphetamine-induced catecholamine release.
What to do
Monitor blood pressure, heart rate and symptoms of palpitations, especially after dose changes. Avoid in patients with uncontrolled hypertension or significant arrhythmia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Salmeterol?
MediHelp rates the interaction as moderate. Dextroamphetamine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have sympathomimetic activity, so combined use can increase heart rate, blood pressure, tremor and anxiety. Patients with cardiovascular disease or arrhythmias are at greater risk.
How serious is the interaction between Dextroamphetamine and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and symptoms of palpitations, especially after dose changes. Avoid in patients with uncontrolled hypertension or significant arrhythmia.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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