Drug interactions
Dextroamphetamine transdermal + Frovatriptan
Severity: Moderate
Dextroamphetamine transdermal and Frovatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can raise central serotonergic activity, so combining them may precipitate serotonin syndrome, with agitation, tremor, hyperthermia, diarrhea and neuromuscular hyperactivity. Risk is greatest at treatment start or after a dose increase.
What this interaction means in plain words
Dextroamphetamine transdermal and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects: amphetamine promotes monoamine release and blocks reuptake while frovatriptan is a 5-HT1B/1D agonist.
What to do
Monitor for signs of serotonin syndrome, especially when starting or increasing either drug. If symptoms appear, stop the amphetamine and other serotonergic agents and give supportive care.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Dextroamphetamine transdermal with Frovatriptan?
MediHelp rates the interaction as moderate. Dextroamphetamine transdermal and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can raise central serotonergic activity, so combining them may precipitate serotonin syndrome, with agitation, tremor, hyperthermia, diarrhea and neuromuscular hyperactivity. Risk is greatest at treatment start or after a dose increase.
How serious is the interaction between Dextroamphetamine transdermal and Frovatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin syndrome, especially when starting or increasing either drug. If symptoms appear, stop the amphetamine and other serotonergic agents and give supportive care.
What other medicines interact with Frovatriptan?
MediHelp also lists interactions of Frovatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Frovatriptan page.
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