Drug interactions
Dextromoramide + Diazepam
Severity: Major
Dextromoramide and Diazepam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextromoramide is a potent opioid, and combined with diazepam it can cause profound sedation, respiratory depression, coma and death. Regulators warn against concurrent opioid and benzodiazepine use.
What this interaction means in plain words
Dextromoramide and Diazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression through opioid mu-receptor agonism and GABA-A potentiation.
What to do
Avoid the combination where possible; if needed, use the lowest doses for the shortest time and monitor respiration and sedation closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Diazepam
Frequently asked questions
Can I take Dextromoramide with Diazepam?
MediHelp rates the interaction as major. Dextromoramide and Diazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dextromoramide is a potent opioid, and combined with diazepam it can cause profound sedation, respiratory depression, coma and death. Regulators warn against concurrent opioid and benzodiazepine use.
How serious is the interaction between Dextromoramide and Diazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if needed, use the lowest doses for the shortest time and monitor respiration and sedation closely.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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