Drug interactions
Dextromoramide + Doxylamine
Severity: Major
Dextromoramide and Doxylamine: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextromoramide is a potent opioid analgesic. With doxylamine, there is a risk of profound sedation, respiratory depression and coma.
What this interaction means in plain words
Dextromoramide and Doxylamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression via opioid receptor agonism and central H1 antagonism.
What to do
Avoid where possible; if needed use the lowest effective doses and monitor sedation and respiratory rate. Counsel patients against alcohol and driving.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dextromoramide and Doxylamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Doxylamine
Frequently asked questions
Can I take Dextromoramide with Doxylamine?
MediHelp rates the interaction as major. Dextromoramide and Doxylamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dextromoramide is a potent opioid analgesic. With doxylamine, there is a risk of profound sedation, respiratory depression and coma.
How serious is the interaction between Dextromoramide and Doxylamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid where possible; if needed use the lowest effective doses and monitor sedation and respiratory rate. Counsel patients against alcohol and driving.
What other medicines interact with Doxylamine?
MediHelp also lists interactions of Doxylamine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Doxylamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
