Drug interactions
Dextromoramide + Phenelzine
Severity: Major
Dextromoramide and Phenelzine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextromoramide is a potent opioid, and MAOIs may cause severe reactions including serotonin toxicity, respiratory depression and hypotension. The combination is best avoided.
What this interaction means in plain words
Dextromoramide and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Probable additive CNS depression and serotonergic effects; mechanism not fully established.
What to do
Avoid during phenelzine therapy and for 14 days afterwards; choose an alternative analgesic. If unavoidable, titrate small doses under close respiratory and hemodynamic monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Dextromoramide with Phenelzine?
MediHelp rates the interaction as major. Dextromoramide and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dextromoramide is a potent opioid, and MAOIs may cause severe reactions including serotonin toxicity, respiratory depression and hypotension. The combination is best avoided.
How serious is the interaction between Dextromoramide and Phenelzine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during phenelzine therapy and for 14 days afterwards; choose an alternative analgesic. If unavoidable, titrate small doses under close respiratory and hemodynamic monitoring.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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