Drug interactions
DHEA herbal + Nifedipine
Severity: Minor
DHEA herbal and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
DHEA may affect CYP3A4 activity and could change nifedipine levels, though the direction and size of any effect are not well documented. Clinical significance is likely small.
What this interaction means in plain words
DHEA herbal and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible modulation of CYP3A4 activity; the mechanism is not firmly established.
What to do
Monitor blood pressure and edema if DHEA supplements are started or stopped during nifedipine therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Frequently asked questions
Can I take DHEA herbal with Nifedipine?
MediHelp rates the interaction as minor. DHEA herbal and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. DHEA may affect CYP3A4 activity and could change nifedipine levels, though the direction and size of any effect are not well documented. Clinical significance is likely small.
How serious is the interaction between DHEA herbal and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema if DHEA supplements are started or stopped during nifedipine therapy.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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