Drug interactions
Diatrizoate + Metformin-repaglinide
Severity: Major
Diatrizoate and Metformin-repaglinide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iodinated contrast media can cause acute kidney injury, which reduces metformin clearance and may lead to lactic acidosis. The risk is greatest in patients with reduced eGFR or those receiving intra-arterial contrast.
What this interaction means in plain words
Diatrizoate and Metformin-repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Contrast-associated acute renal impairment reduces renal elimination of metformin, causing accumulation.
What to do
Withhold metformin at the time of or before the procedure in at-risk patients and restart only after renal function is re-evaluated, typically at 48 hours, and found stable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Diatrizoate with Metformin-repaglinide?
MediHelp rates the interaction as major. Diatrizoate and Metformin-repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Iodinated contrast media can cause acute kidney injury, which reduces metformin clearance and may lead to lactic acidosis. The risk is greatest in patients with reduced eGFR or those receiving intra-arterial contrast.
How serious is the interaction between Diatrizoate and Metformin-repaglinide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Withhold metformin at the time of or before the procedure in at-risk patients and restart only after renal function is re-evaluated, typically at 48 hours, and found stable.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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