Drug interactions
Diatrizoate + Saxagliptin-metformin
Severity: Major
Diatrizoate and Saxagliptin-metformin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iodinated contrast can cause acute kidney injury, which reduces metformin clearance and may lead to metformin accumulation and lactic acidosis. Risk is greatest with impaired renal function or intra-arterial contrast.
What this interaction means in plain words
Diatrizoate and Saxagliptin-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Contrast-induced renal impairment reduces renal elimination of metformin, leading to accumulation.
What to do
Hold metformin at the time of or before contrast in patients with eGFR below 30, liver disease, or intra-arterial dosing, and restart after 48 hours only once renal function is confirmed stable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Saxagliptin-metformin
Frequently asked questions
Can I take Diatrizoate with Saxagliptin-metformin?
MediHelp rates the interaction as major. Diatrizoate and Saxagliptin-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Iodinated contrast can cause acute kidney injury, which reduces metformin clearance and may lead to metformin accumulation and lactic acidosis. Risk is greatest with impaired renal function or intra-arterial contrast.
How serious is the interaction between Diatrizoate and Saxagliptin-metformin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold metformin at the time of or before contrast in patients with eGFR below 30, liver disease, or intra-arterial dosing, and restart after 48 hours only once renal function is confirmed stable.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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