Drug interactions
Diazepam + Difenoxin
Severity: Moderate
Diazepam and Difenoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difenoxin is an opioid antidiarrheal related to diphenoxylate, and with diazepam it can add to CNS depression. Overdose risk, especially in children and the elderly, is increased.
What this interaction means in plain words
Diazepam and Difenoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Difenoxin belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression from opioid agonism and benzodiazepine GABA-A potentiation.
What to do
Use recommended doses only and monitor for drowsiness and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Difenoxin
Frequently asked questions
Can I take Diazepam with Difenoxin?
MediHelp rates the interaction as moderate. Diazepam and Difenoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difenoxin is an opioid antidiarrheal related to diphenoxylate, and with diazepam it can add to CNS depression. Overdose risk, especially in children and the elderly, is increased.
How serious is the interaction between Diazepam and Difenoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use recommended doses only and monitor for drowsiness and respiratory depression.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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