Drug interactions
Diazepam + Dipipanone
Severity: Major
Diazepam and Dipipanone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipipanone is a strong opioid analgesic, and with diazepam can cause profound sedation, respiratory depression, coma and death.
What this interaction means in plain words
Diazepam and Dipipanone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression via opioid and GABA-A receptor mechanisms.
What to do
Avoid combining where possible; otherwise use the lowest effective doses for the shortest time and monitor respiration and sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Diazepam
Frequently asked questions
Can I take Diazepam with Dipipanone?
MediHelp rates the interaction as major. Diazepam and Dipipanone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dipipanone is a strong opioid analgesic, and with diazepam can cause profound sedation, respiratory depression, coma and death.
How serious is the interaction between Diazepam and Dipipanone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; otherwise use the lowest effective doses for the shortest time and monitor respiration and sedation.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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