Drug interactions
Diazepam + Encorafenib
Severity: Moderate
Diazepam and Encorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib has mixed inhibitory and inducing effects on CYP3A4, so exposure to diazepam may rise or fall unpredictably. This could cause excess sedation or reduced anxiolytic or anticonvulsant effect.
What this interaction means in plain words
Diazepam and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Encorafenib belongs to Oncology.
Why it happens
Encorafenib both inhibits and induces CYP3A4, altering the metabolism of diazepam, which is partly a CYP3A4 substrate.
What to do
Monitor for sedation and for loss of diazepam effect when starting, stopping or changing encorafenib. Adjust the diazepam dose according to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Encorafenib
Frequently asked questions
Can I take Diazepam with Encorafenib?
MediHelp rates the interaction as moderate. Diazepam and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib has mixed inhibitory and inducing effects on CYP3A4, so exposure to diazepam may rise or fall unpredictably. This could cause excess sedation or reduced anxiolytic or anticonvulsant effect.
How serious is the interaction between Diazepam and Encorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and for loss of diazepam effect when starting, stopping or changing encorafenib. Adjust the diazepam dose according to clinical response.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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