Drug interactions
Diazepam + Esketamine intranasal
Severity: Moderate
Diazepam and Esketamine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine causes sedation and dissociation, and combining it with benzodiazepines may increase drowsiness and impair alertness. Benzodiazepines may also reduce the antidepressant efficacy of esketamine.
What this interaction means in plain words
Diazepam and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through NMDA antagonism and GABA-A enhancement.
What to do
Monitor sedation after each esketamine dose per the observation protocol. Minimize benzodiazepine use where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Frequently asked questions
Can I take Diazepam with Esketamine intranasal?
MediHelp rates the interaction as moderate. Diazepam and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine causes sedation and dissociation, and combining it with benzodiazepines may increase drowsiness and impair alertness. Benzodiazepines may also reduce the antidepressant efficacy of esketamine.
How serious is the interaction between Diazepam and Esketamine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation after each esketamine dose per the observation protocol. Minimize benzodiazepine use where possible.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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