Drug interactions
Diazepam + Ethinyl estradiol-norgestimate
Severity: Minor
Diazepam and Ethinyl estradiol-norgestimate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral contraceptives can reduce the clearance of diazepam, leading to higher levels and more sedation. The effect is generally modest.
What this interaction means in plain words
Diazepam and Ethinyl estradiol-norgestimate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diazepam belongs to Musculoskeletal; Ethinyl estradiol-norgestimate belongs to Endocrine.
Why it happens
Estrogen-containing contraceptives inhibit oxidative metabolism of diazepam via CYP3A4 and CYP2C19.
What to do
Monitor for increased sedation or impaired psychomotor performance and lower the diazepam dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Diazepam
Frequently asked questions
Can I take Diazepam with Ethinyl estradiol-norgestimate?
MediHelp rates the interaction as minor. Diazepam and Ethinyl estradiol-norgestimate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral contraceptives can reduce the clearance of diazepam, leading to higher levels and more sedation. The effect is generally modest.
How serious is the interaction between Diazepam and Ethinyl estradiol-norgestimate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation or impaired psychomotor performance and lower the diazepam dose if needed.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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