Drug interactions
Diazepam + Fexinidazole
Severity: Moderate
Diazepam and Fexinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP3A4 and so increase exposure to diazepam, which is partly cleared by this enzyme. This could intensify sedation and psychomotor impairment.
What this interaction means in plain words
Diazepam and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated diazepam metabolism, with additive CNS effects possible.
What to do
Monitor for excess sedation and reduce the diazepam dose if needed during the short fexinidazole course. Consider an alternative anxiolytic or sedative if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Diazepam and Fexinidazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Diazepam
Frequently asked questions
Can I take Diazepam with Fexinidazole?
MediHelp rates the interaction as moderate. Diazepam and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may inhibit CYP3A4 and so increase exposure to diazepam, which is partly cleared by this enzyme. This could intensify sedation and psychomotor impairment.
How serious is the interaction between Diazepam and Fexinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and reduce the diazepam dose if needed during the short fexinidazole course. Consider an alternative anxiolytic or sedative if feasible.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
