Drug interactions
Diazepam + Flurazepam
Severity: Moderate
Diazepam and Flurazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two benzodiazepines together increases sedation, psychomotor impairment and risk of respiratory depression. Flurazepam has long-acting active metabolites, so effects can persist and accumulate, especially in older adults.
What this interaction means in plain words
Diazepam and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive GABA-A receptor potentiation by two benzodiazepines.
What to do
Avoid combining; use one benzodiazepine at the lowest effective dose. If overlap occurs, monitor sedation and breathing and watch for next-day impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Frequently asked questions
Can I take Diazepam with Flurazepam?
MediHelp rates the interaction as moderate. Diazepam and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using two benzodiazepines together increases sedation, psychomotor impairment and risk of respiratory depression. Flurazepam has long-acting active metabolites, so effects can persist and accumulate, especially in older adults.
How serious is the interaction between Diazepam and Flurazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; use one benzodiazepine at the lowest effective dose. If overlap occurs, monitor sedation and breathing and watch for next-day impairment.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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