Drug interactions
Diazepam + Gabapentin
Severity: Moderate
Diazepam and Gabapentin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, and together they increase sedation, dizziness and cognitive impairment. Respiratory depression is a particular concern in older patients, those with lung disease, and with other sedatives or opioids.
What this interaction means in plain words
Diazepam and Gabapentin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Gabapentin belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABAergic benzodiazepine action and gabapentinoid modulation of calcium channels.
What to do
Use the lowest effective doses and monitor for sedation and respiratory depression, especially at initiation and in high-risk patients; counsel against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Gabapentin
Frequently asked questions
Can I take Diazepam with Gabapentin?
MediHelp rates the interaction as moderate. Diazepam and Gabapentin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS, and together they increase sedation, dizziness and cognitive impairment. Respiratory depression is a particular concern in older patients, those with lung disease, and with other sedatives or opioids.
How serious is the interaction between Diazepam and Gabapentin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression, especially at initiation and in high-risk patients; counsel against driving and alcohol.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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