Drug interactions
Diazepam + Hydrocortisone
Severity: Minor
Diazepam and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone is only a weak CYP3A4 inducer, and diazepam is cleared by CYP2C19 and CYP3A4, so a meaningful loss of effect is unlikely.
What this interaction means in plain words
Diazepam and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diazepam belongs to Musculoskeletal; Hydrocortisone belongs to Endocrine.
Why it happens
Theoretical weak CYP3A4 induction.
What to do
No adjustment needed; titrate diazepam to clinical effect as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Diazepam
Frequently asked questions
Can I take Diazepam with Hydrocortisone?
MediHelp rates the interaction as minor. Diazepam and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrocortisone is only a weak CYP3A4 inducer, and diazepam is cleared by CYP2C19 and CYP3A4, so a meaningful loss of effect is unlikely.
How serious is the interaction between Diazepam and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment needed; titrate diazepam to clinical effect as usual.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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