Drug interactions
Diazepam + Indinavir
Severity: Moderate
Diazepam and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and may increase diazepam concentrations, causing prolonged sedation and possible respiratory depression.
What this interaction means in plain words
Diazepam and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by indinavir reduces diazepam metabolism.
What to do
Reduce the diazepam dose and monitor for oversedation. Prefer lorazepam if a benzodiazepine is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Frequently asked questions
Can I take Diazepam with Indinavir?
MediHelp rates the interaction as moderate. Diazepam and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir inhibits CYP3A4 and may increase diazepam concentrations, causing prolonged sedation and possible respiratory depression.
How serious is the interaction between Diazepam and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the diazepam dose and monitor for oversedation. Prefer lorazepam if a benzodiazepine is needed.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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