Drug interactions
Diazepam + Lofepramine
Severity: Moderate
Diazepam and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine, a tricyclic antidepressant, has sedative properties and adds to the sedation and psychomotor impairment from diazepam. Anticholinergic and hypotensive effects may contribute to falls.
What this interaction means in plain words
Diazepam and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from antihistaminic effects of the tricyclic and GABA-A potentiation by diazepam.
What to do
Monitor for drowsiness and falls, particularly in older patients, and use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Frequently asked questions
Can I take Diazepam with Lofepramine?
MediHelp rates the interaction as moderate. Diazepam and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine, a tricyclic antidepressant, has sedative properties and adds to the sedation and psychomotor impairment from diazepam. Anticholinergic and hypotensive effects may contribute to falls.
How serious is the interaction between Diazepam and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness and falls, particularly in older patients, and use the lowest effective doses.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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