Drug interactions
Diazepam + Lumacaftor / ivacaftor
Severity: Moderate
Diazepam and Lumacaftor / ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor/ivacaftor can alter diazepam exposure, and the net direction is hard to predict because lumacaftor may induce while ivacaftor may inhibit CYP2C19. Diazepam efficacy may be reduced or its sedative effects may be increased.
What this interaction means in plain words
Diazepam and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing effects on CYP2C19 (induction by lumacaftor, inhibition by ivacaftor) and CYP3A induction by lumacaftor may change diazepam metabolism.
What to do
Monitor clinical response to diazepam, watching for loss of effect or excess sedation, after starting or stopping lumacaftor/ivacaftor. Adjust the diazepam dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Frequently asked questions
Can I take Diazepam with Lumacaftor / ivacaftor?
MediHelp rates the interaction as moderate. Diazepam and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor/ivacaftor can alter diazepam exposure, and the net direction is hard to predict because lumacaftor may induce while ivacaftor may inhibit CYP2C19. Diazepam efficacy may be reduced or its sedative effects may be increased.
How serious is the interaction between Diazepam and Lumacaftor / ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to diazepam, watching for loss of effect or excess sedation, after starting or stopping lumacaftor/ivacaftor. Adjust the diazepam dose according to response.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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