Drug interactions
Diazepam + Lumefantrine
Severity: Minor
Diazepam and Lumefantrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine is a weak CYP3A4 inducer in some data, but its effect on diazepam exposure is not well established. Any change in diazepam levels is likely small and of limited clinical importance.
What this interaction means in plain words
Diazepam and Lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible modest CYP3A4 effect altering diazepam clearance; the mechanism is not firmly established.
What to do
No routine dose change is needed; observe for reduced diazepam effect during antimalarial therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diazepam
Frequently asked questions
Can I take Diazepam with Lumefantrine?
MediHelp rates the interaction as minor. Diazepam and Lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumefantrine is a weak CYP3A4 inducer in some data, but its effect on diazepam exposure is not well established. Any change in diazepam levels is likely small and of limited clinical importance.
How serious is the interaction between Diazepam and Lumefantrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; observe for reduced diazepam effect during antimalarial therapy.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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