Drug interactions
Diazepam + Marijuana
Severity: Moderate
Diazepam and Marijuana: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis adds to the sedative and psychomotor-impairing effects of diazepam, increasing the risk of drowsiness, impaired coordination and poor judgment. Cannabidiol may also raise benzodiazepine exposure by inhibiting CYP enzymes.
What this interaction means in plain words
Diazepam and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with possible CYP3A4/CYP2C19 inhibition by cannabinoids (notably cannabidiol) reducing diazepam clearance.
What to do
Counsel patients to avoid driving or hazardous tasks and monitor for excessive sedation. Reduce the diazepam dose if oversedation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Frequently asked questions
Can I take Diazepam with Marijuana?
MediHelp rates the interaction as moderate. Diazepam and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis adds to the sedative and psychomotor-impairing effects of diazepam, increasing the risk of drowsiness, impaired coordination and poor judgment. Cannabidiol may also raise benzodiazepine exposure by inhibiting CYP enzymes.
How serious is the interaction between Diazepam and Marijuana?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving or hazardous tasks and monitor for excessive sedation. Reduce the diazepam dose if oversedation develops.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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