Drug interactions
Diazepam + Metronidazole
Severity: Minor
Diazepam and Metronidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole may modestly reduce the clearance of diazepam, leading to higher levels and prolonged sedation. The effect is typically small but may matter in older patients or those with liver impairment.
What this interaction means in plain words
Diazepam and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diazepam belongs to Musculoskeletal; Metronidazole belongs to Anti Parasitic.
Why it happens
Metronidazole may weakly inhibit the hepatic oxidative metabolism of diazepam.
What to do
Monitor for increased drowsiness during metronidazole therapy and reduce the diazepam dose if oversedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diazepam
Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Frequently asked questions
Can I take Diazepam with Metronidazole?
MediHelp rates the interaction as minor. Diazepam and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metronidazole may modestly reduce the clearance of diazepam, leading to higher levels and prolonged sedation. The effect is typically small but may matter in older patients or those with liver impairment.
How serious is the interaction between Diazepam and Metronidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased drowsiness during metronidazole therapy and reduce the diazepam dose if oversedation occurs.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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