Drug interactions
Diazepam + Miconazole vaginal
Severity: Minor
Diazepam and Miconazole vaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vaginal miconazole is absorbed to a small degree, but it is a CYP3A4 inhibitor and could slightly increase diazepam exposure. The clinical effect is usually minor and limited to extra drowsiness.
What this interaction means in plain words
Diazepam and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4-mediated diazepam metabolism by systemically absorbed miconazole.
What to do
No dose change is generally required; watch for increased sedation, particularly with prolonged or repeated courses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diazepam
Frequently asked questions
Can I take Diazepam with Miconazole vaginal?
MediHelp rates the interaction as minor. Diazepam and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vaginal miconazole is absorbed to a small degree, but it is a CYP3A4 inhibitor and could slightly increase diazepam exposure. The clinical effect is usually minor and limited to extra drowsiness.
How serious is the interaction between Diazepam and Miconazole vaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required; watch for increased sedation, particularly with prolonged or repeated courses.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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