Drug interactions
Diazepam + Olanzapine / samidorphan
Severity: Moderate
Diazepam and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine and diazepam together increase sedation and the risk of orthostatic hypotension, with syncope or falls possible. Parenteral benzodiazepines with olanzapine have additionally been associated with cardiorespiratory depression.
What this interaction means in plain words
Diazepam and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and alpha-adrenergic related hypotension from olanzapine combined with benzodiazepine effects.
What to do
Monitor sedation and blood pressure, especially on initiation and dose increases, and counsel patients to rise slowly. Avoid parenteral diazepam given close in time to injectable olanzapine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Frequently asked questions
Can I take Diazepam with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Diazepam and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine and diazepam together increase sedation and the risk of orthostatic hypotension, with syncope or falls possible. Parenteral benzodiazepines with olanzapine have additionally been associated with cardiorespiratory depression.
How serious is the interaction between Diazepam and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure, especially on initiation and dose increases, and counsel patients to rise slowly. Avoid parenteral diazepam given close in time to injectable olanzapine.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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