Drug interactions
Diazepam + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Moderate
Diazepam and Ombitasvir / paritaprevir / ritonavir and dasabuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-containing regimens inhibit CYP3A4, which may raise diazepam exposure, though ritonavir's induction of other pathways can lower active metabolite levels. Clinical effect is variable, with sedation or reduced response possible.
What this interaction means in plain words
Diazepam and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mixed CYP3A4 inhibition and induction of other metabolic pathways by the ritonavir-containing regimen.
What to do
Monitor for sedation and efficacy when starting or stopping the regimen. Adjust the diazepam dose based on response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Frequently asked questions
Can I take Diazepam with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as moderate. Diazepam and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir-containing regimens inhibit CYP3A4, which may raise diazepam exposure, though ritonavir's induction of other pathways can lower active metabolite levels. Clinical effect is variable, with sedation or reduced response possible.
How serious is the interaction between Diazepam and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and efficacy when starting or stopping the regimen. Adjust the diazepam dose based on response.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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