Drug interactions
Diazepam + Parecoxib
Severity: Minor
Diazepam and Parecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib's active metabolite valdecoxib is a weak CYP2C19 inhibitor, which could modestly raise diazepam exposure. A clinically important effect is unlikely with short perioperative use.
What this interaction means in plain words
Diazepam and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak inhibition of CYP2C19 mediated diazepam metabolism.
What to do
No dose adjustment is usually required; watch for increased sedation if both are used together.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diazepam
Frequently asked questions
Can I take Diazepam with Parecoxib?
MediHelp rates the interaction as minor. Diazepam and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Parecoxib's active metabolite valdecoxib is a weak CYP2C19 inhibitor, which could modestly raise diazepam exposure. A clinically important effect is unlikely with short perioperative use.
How serious is the interaction between Diazepam and Parecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required; watch for increased sedation if both are used together.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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