Drug interactions
Diazepam + Pimozide
Severity: Moderate
Diazepam and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, so combined use can increase drowsiness and impaired coordination. Pimozide also prolongs the QT interval, but diazepam does not meaningfully affect this and is not known to alter its metabolism significantly.
What this interaction means in plain words
Diazepam and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for oversedation and falls, and keep doses low in older adults. Continue routine ECG monitoring for pimozide as indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Diazepam with Pimozide?
MediHelp rates the interaction as moderate. Diazepam and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, so combined use can increase drowsiness and impaired coordination. Pimozide also prolongs the QT interval, but diazepam does not meaningfully affect this and is not known to alter its metabolism significantly.
How serious is the interaction between Diazepam and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and falls, and keep doses low in older adults. Continue routine ECG monitoring for pimozide as indicated.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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