Drug interactions
Diazepam + Sage
Severity: Minor
Diazepam and Sage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sage may have sedative properties that add to diazepam, while some species contain thujone, a GABA antagonist that could in theory reduce benzodiazepine effect or lower the seizure threshold. Evidence is theoretical.
What this interaction means in plain words
Diazepam and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive sedation or GABA-A antagonism by thujone-containing sage species.
What to do
Advise patients to avoid concentrated sage oil or supplements, especially if taking diazepam for seizure control.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diazepam
Frequently asked questions
Can I take Diazepam with Sage?
MediHelp rates the interaction as minor. Diazepam and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sage may have sedative properties that add to diazepam, while some species contain thujone, a GABA antagonist that could in theory reduce benzodiazepine effect or lower the seizure threshold. Evidence is theoretical.
How serious is the interaction between Diazepam and Sage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid concentrated sage oil or supplements, especially if taking diazepam for seizure control.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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