Drug interactions
Diazepam + Scullcap
Severity: Moderate
Diazepam and Scullcap: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Scullcap has traditionally been used as a sedative herb and may add to the central nervous system depression produced by diazepam. Excess drowsiness and impaired psychomotor performance could result. Evidence is largely theoretical.
What this interaction means in plain words
Diazepam and Scullcap can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects, possibly through GABAergic activity of scullcap constituents.
What to do
Advise patients to avoid scullcap supplements while taking diazepam, or monitor for excessive sedation and counsel against driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Diazepam and Scullcap, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Diazepam
Frequently asked questions
Can I take Diazepam with Scullcap?
MediHelp rates the interaction as moderate. Diazepam and Scullcap can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Scullcap has traditionally been used as a sedative herb and may add to the central nervous system depression produced by diazepam. Excess drowsiness and impaired psychomotor performance could result. Evidence is largely theoretical.
How serious is the interaction between Diazepam and Scullcap?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid scullcap supplements while taking diazepam, or monitor for excessive sedation and counsel against driving.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
