Drug interactions
Diazepam + Triazolam
Severity: Moderate
Diazepam and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use of diazepam and triazolam results in additive sedation, amnesia, psychomotor impairment and respiratory depression. Combining benzodiazepines adds risk without clear benefit.
What this interaction means in plain words
Diazepam and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive GABA-A receptor potentiation.
What to do
Avoid combining benzodiazepines when possible; if both are needed, minimize doses and monitor for oversedation and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Frequently asked questions
Can I take Diazepam with Triazolam?
MediHelp rates the interaction as moderate. Diazepam and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of diazepam and triazolam results in additive sedation, amnesia, psychomotor impairment and respiratory depression. Combining benzodiazepines adds risk without clear benefit.
How serious is the interaction between Diazepam and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining benzodiazepines when possible; if both are needed, minimize doses and monitor for oversedation and falls.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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