Drug interactions
Diazepam + Triclofos
Severity: Moderate
Diazepam and Triclofos: moderate interaction.
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For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclofos is a sedative-hypnotic whose active metabolite trichloroethanol causes CNS depression. With diazepam, sedation and respiratory depression are additive, and this is of particular concern in children and older adults.
What this interaction means in plain words
Diazepam and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from trichloroethanol and diazepam acting at GABA-A receptors.
What to do
Use reduced doses of each drug and monitor level of consciousness and respiration; avoid driving or hazardous tasks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Frequently asked questions
Can I take Diazepam with Triclofos?
MediHelp rates the interaction as moderate. Diazepam and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclofos is a sedative-hypnotic whose active metabolite trichloroethanol causes CNS depression. With diazepam, sedation and respiratory depression are additive, and this is of particular concern in children and older adults.
How serious is the interaction between Diazepam and Triclofos?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced doses of each drug and monitor level of consciousness and respiration; avoid driving or hazardous tasks.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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