Drug interactions
Diazepam + Valerian
Severity: Minor
Diazepam and Valerian: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valerian has mild sedative properties and may add to the CNS depression of diazepam. Clinical evidence of significant harm is limited.
What this interaction means in plain words
Diazepam and Valerian have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive sedation, possibly via GABAergic activity of valerian constituents.
What to do
Advise patients to avoid combining them or to watch for excess drowsiness. Avoid driving if sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diazepam
Frequently asked questions
Can I take Diazepam with Valerian?
MediHelp rates the interaction as minor. Diazepam and Valerian have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valerian has mild sedative properties and may add to the CNS depression of diazepam. Clinical evidence of significant harm is limited.
How serious is the interaction between Diazepam and Valerian?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid combining them or to watch for excess drowsiness. Avoid driving if sedation occurs.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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