Drug interactions
Diazepam + Zolpidem
Severity: Moderate
Diazepam and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs enhance GABA-A mediated inhibition, so taking them together increases sedation, psychomotor impairment, and the risk of respiratory depression. Falls, next-day impairment and complex sleep behaviors are more likely, especially in older adults.
What this interaction means in plain words
Diazepam and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Zolpidem belongs to Central Nervous System.
Why it happens
Additive CNS depression through positive modulation of GABA-A receptors.
What to do
Avoid routine co-prescription of two GABA-A hypnotic-sedatives; if combined, use the lowest effective doses and counsel on driving and fall risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Zolpidem
Frequently asked questions
Can I take Diazepam with Zolpidem?
MediHelp rates the interaction as moderate. Diazepam and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs enhance GABA-A mediated inhibition, so taking them together increases sedation, psychomotor impairment, and the risk of respiratory depression. Falls, next-day impairment and complex sleep behaviors are more likely, especially in older adults.
How serious is the interaction between Diazepam and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine co-prescription of two GABA-A hypnotic-sedatives; if combined, use the lowest effective doses and counsel on driving and fall risk.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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