Drug interactions
Diazepam intranasal + Efavirenz
Severity: Moderate
Diazepam intranasal and Efavirenz: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz has opposing effects on diazepam metabolism, inducing CYP3A4 and inhibiting CYP2C19, so diazepam exposure may change unpredictably. Additive sedation and CNS depression can also occur.
What this interaction means in plain words
Diazepam intranasal and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Efavirenz modulates CYP3A4 and CYP2C19 metabolism of diazepam, and both have CNS depressant effects.
What to do
Monitor seizure control and sedation, and adjust the diazepam dose if the response changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Diazepam intranasal with Efavirenz?
MediHelp rates the interaction as moderate. Diazepam intranasal and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz has opposing effects on diazepam metabolism, inducing CYP3A4 and inhibiting CYP2C19, so diazepam exposure may change unpredictably. Additive sedation and CNS depression can also occur.
How serious is the interaction between Diazepam intranasal and Efavirenz?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and sedation, and adjust the diazepam dose if the response changes.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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