Drug interactions
Diazepam intranasal + Isocarboxazid
Severity: Moderate
Diazepam intranasal and Isocarboxazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diazepam is a benzodiazepine that depresses the CNS, and isocarboxazid can also cause sedation and dizziness. Together they may increase drowsiness, psychomotor impairment and the risk of falls.
What this interaction means in plain words
Diazepam intranasal and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for excessive sedation, avoid driving or hazardous tasks, and use the lowest effective diazepam dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Diazepam intranasal with Isocarboxazid?
MediHelp rates the interaction as moderate. Diazepam intranasal and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diazepam is a benzodiazepine that depresses the CNS, and isocarboxazid can also cause sedation and dizziness. Together they may increase drowsiness, psychomotor impairment and the risk of falls.
How serious is the interaction between Diazepam intranasal and Isocarboxazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, avoid driving or hazardous tasks, and use the lowest effective diazepam dose.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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