Drug interactions
Diazepam intranasal + Ketoconazole
Severity: Moderate
Diazepam intranasal and Ketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole can slow the elimination of diazepam and increase its effects. This raises the risk of excessive sedation, and potentially respiratory depression.
What this interaction means in plain words
Diazepam intranasal and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ketoconazole inhibits CYP3A4 and CYP2C19, the main enzymes that metabolize diazepam.
What to do
Monitor for oversedation and respiratory depression, and avoid additional CNS depressants. Consider a reduced diazepam dose or fewer repeat doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Diazepam intranasal with Ketoconazole?
MediHelp rates the interaction as moderate. Diazepam intranasal and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole can slow the elimination of diazepam and increase its effects. This raises the risk of excessive sedation, and potentially respiratory depression.
How serious is the interaction between Diazepam intranasal and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and respiratory depression, and avoid additional CNS depressants. Consider a reduced diazepam dose or fewer repeat doses.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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