Drug interactions
Diazepam intranasal + Lorazepam
Severity: Moderate
Diazepam intranasal and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two benzodiazepines taken together add to each other's sedative and respiratory depressant effects. This raises the risk of excessive drowsiness, impaired psychomotor performance and respiratory depression.
What this interaction means in plain words
Diazepam intranasal and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive positive allosteric modulation of GABA-A receptors by both benzodiazepines.
What to do
Avoid routine duplicate benzodiazepine therapy; if both are needed, for example for seizure rescue, monitor level of consciousness and respiration and reduce doses as appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Diazepam intranasal and Lorazepam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lorazepam
Frequently asked questions
Can I take Diazepam intranasal with Lorazepam?
MediHelp rates the interaction as moderate. Diazepam intranasal and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Two benzodiazepines taken together add to each other's sedative and respiratory depressant effects. This raises the risk of excessive drowsiness, impaired psychomotor performance and respiratory depression.
How serious is the interaction between Diazepam intranasal and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine duplicate benzodiazepine therapy; if both are needed, for example for seizure rescue, monitor level of consciousness and respiration and reduce doses as appropriate.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
