Drug interactions
Diazepam intranasal + Lorlatinib
Severity: Moderate
Diazepam intranasal and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib may speed up the elimination of diazepam, lowering its concentrations. This could reduce seizure control with intranasal diazepam rescue therapy.
What this interaction means in plain words
Diazepam intranasal and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lorlatinib induces CYP3A4, which contributes to diazepam metabolism.
What to do
Monitor for reduced anticonvulsant or anxiolytic effect and be prepared to adjust the dose or use an alternative benzodiazepine. Reassess the dose when lorlatinib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Diazepam intranasal with Lorlatinib?
MediHelp rates the interaction as moderate. Diazepam intranasal and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib may speed up the elimination of diazepam, lowering its concentrations. This could reduce seizure control with intranasal diazepam rescue therapy.
How serious is the interaction between Diazepam intranasal and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced anticonvulsant or anxiolytic effect and be prepared to adjust the dose or use an alternative benzodiazepine. Reassess the dose when lorlatinib is stopped.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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