Drug interactions
Diazepam intranasal + Oxazepam
Severity: Moderate
Diazepam intranasal and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two benzodiazepines together duplicate effects and increase sedation, psychomotor impairment and respiratory depression. Intranasal diazepam is used for seizure emergencies, so excess sedation may complicate recovery monitoring.
What this interaction means in plain words
Diazepam intranasal and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive GABA-A receptor potentiation.
What to do
Monitor respiratory status and level of consciousness after diazepam use. Avoid routine duplicate benzodiazepine therapy and review oxazepam dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Frequently asked questions
Can I take Diazepam intranasal with Oxazepam?
MediHelp rates the interaction as moderate. Diazepam intranasal and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Two benzodiazepines together duplicate effects and increase sedation, psychomotor impairment and respiratory depression. Intranasal diazepam is used for seizure emergencies, so excess sedation may complicate recovery monitoring.
How serious is the interaction between Diazepam intranasal and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory status and level of consciousness after diazepam use. Avoid routine duplicate benzodiazepine therapy and review oxazepam dosing.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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