Drug interactions
Diazepam intranasal + Pantoprazole
Severity: Minor
Diazepam intranasal and Pantoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diazepam is partly cleared by CYP2C19, and pantoprazole is a weak inhibitor of this enzyme. Diazepam levels may rise slightly with increased sedation, though the effect is usually small.
What this interaction means in plain words
Diazepam intranasal and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP2C19 inhibition by pantoprazole reduces diazepam metabolism.
What to do
Monitor for excess sedation and psychomotor impairment, especially in older patients or CYP2C19 poor metabolizers.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Frequently asked questions
Can I take Diazepam intranasal with Pantoprazole?
MediHelp rates the interaction as minor. Diazepam intranasal and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diazepam is partly cleared by CYP2C19, and pantoprazole is a weak inhibitor of this enzyme. Diazepam levels may rise slightly with increased sedation, though the effect is usually small.
How serious is the interaction between Diazepam intranasal and Pantoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and psychomotor impairment, especially in older patients or CYP2C19 poor metabolizers.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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