Drug interactions
Diazepam intranasal + Paroxetine
Severity: Moderate
Diazepam intranasal and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining diazepam with paroxetine may increase drowsiness, psychomotor impairment and cognitive slowing. Paroxetine has sedative potential in some patients and diazepam is a CNS depressant, so effects can add up.
What this interaction means in plain words
Diazepam intranasal and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression.
What to do
Monitor for excess sedation and impaired psychomotor performance, and advise patients to avoid driving and alcohol. Reduce the benzodiazepine dose if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Diazepam intranasal with Paroxetine?
MediHelp rates the interaction as moderate. Diazepam intranasal and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining diazepam with paroxetine may increase drowsiness, psychomotor impairment and cognitive slowing. Paroxetine has sedative potential in some patients and diazepam is a CNS depressant, so effects can add up.
How serious is the interaction between Diazepam intranasal and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and impaired psychomotor performance, and advise patients to avoid driving and alcohol. Reduce the benzodiazepine dose if sedation is excessive.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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