Drug interactions
Diazepam intranasal + Phenelzine
Severity: Moderate
Diazepam intranasal and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, so combined use can increase sedation, psychomotor impairment and dizziness. The effect is usually manageable but may be clinically important in older or frail patients.
What this interaction means in plain words
Diazepam intranasal and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through benzodiazepine GABA-A potentiation and MAO inhibitor sedative effects.
What to do
Monitor for excessive sedation and impaired coordination, and use the lowest effective diazepam dose. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Diazepam intranasal with Phenelzine?
MediHelp rates the interaction as moderate. Diazepam intranasal and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS, so combined use can increase sedation, psychomotor impairment and dizziness. The effect is usually manageable but may be clinically important in older or frail patients.
How serious is the interaction between Diazepam intranasal and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and impaired coordination, and use the lowest effective diazepam dose. Advise patients to avoid driving and alcohol.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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