Drug interactions
Dichlorphenamide + Eprosartan-hydrochlorothiazide
Severity: Moderate
Dichlorphenamide and Eprosartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide is a carbonic anhydrase inhibitor that increases urinary potassium and bicarbonate loss. Combined with hydrochlorothiazide it can cause pronounced hypokalemia and metabolic acidosis. The eprosartan component only partly offsets the potassium loss.
What this interaction means in plain words
Dichlorphenamide and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Eprosartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive renal potassium wasting from carbonic anhydrase inhibition and thiazide-induced distal sodium delivery.
What to do
Monitor serum potassium and bicarbonate at baseline and periodically during combined therapy. Correct hypokalemia and consider dose reduction if acidosis develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Dichlorphenamide and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide is a carbonic anhydrase inhibitor that increases urinary potassium and bicarbonate loss. Combined with hydrochlorothiazide it can cause pronounced hypokalemia and metabolic acidosis. The eprosartan component only partly offsets the potassium loss.
How serious is the interaction between Dichlorphenamide and Eprosartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate at baseline and periodically during combined therapy. Correct hypokalemia and consider dose reduction if acidosis develops.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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