Drug interactions
Dichlorphenamide + Erlotinib
Severity: Moderate
Dichlorphenamide and Erlotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide causes potassium loss and erlotinib-related diarrhea can add to potassium and fluid losses. Hypokalemia may then worsen and predispose to arrhythmia or weakness.
What this interaction means in plain words
Dichlorphenamide and Erlotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Erlotinib belongs to Oncology.
Why it happens
Additive potassium loss through renal bicarbonate/potassium wasting and gastrointestinal losses.
What to do
Monitor serum potassium and bicarbonate periodically, particularly if diarrhea develops. Replace potassium as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Erlotinib?
MediHelp rates the interaction as moderate. Dichlorphenamide and Erlotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide causes potassium loss and erlotinib-related diarrhea can add to potassium and fluid losses. Hypokalemia may then worsen and predispose to arrhythmia or weakness.
How serious is the interaction between Dichlorphenamide and Erlotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate periodically, particularly if diarrhea develops. Replace potassium as required.
What other medicines interact with Erlotinib?
MediHelp also lists interactions of Erlotinib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Erlotinib page.
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